Computational Biophysicist
D. E. Shaw Research is seeking computational chemists and biologists, as well as other computational scientists with a track record of achievement, to join our New York-based team. Relevant areas of experience might include direct application of molecular dynamics or other computational methods to drug discovery, investigation of conformational changes relevant to the function of protein kinases, ion channels, or other biomolecules, structural modeling of protein-protein complexes involved in signal transduction or other cellular processes, or study of fundamental biophysical problems, such as protein and RNA folding. Specific knowledge of any of these areas is less critical, however, than strong research skills, and a history of innovation and accomplishment.
Individuals with excellent writing, editing, and proofreading skills sought to work with a team of world-class scientists and engineers on the preparation of scientific manuscripts. Ideal candidates should excel at working independently, problem-solving, and managing multiple editorial projects. A scientific background is preferred, but not required.
Hardware Architect and ASIC Engineer
Successful candidates will display exceptional intellectual ability and will have an outstanding record of innovation and achievement. Experience in the architecture, analysis, and implementation of complex, high-performance hardware solutions based on the latest custom technologies is desirable. Particularly relevant areas of expertise might include parallel computation, high-speed interconnection networks, digital systems simulation, and high-speed (>1 GHz) ASIC design.
Machine Learning Engineer
Successful hires will expand the group's ongoing efforts applying machine learning to drug discovery, biomolecular simulation, and biophysics. Ideal candidates will have demonstrated expertise in developing deep learning techniques, as well as strong Python programming skills. Relevant areas of experience might include molecular dynamics, structural biology, medicinal chemistry, cheminformatics, and/or quantum chemistry, but specific knowledge of any of these areas is less critical than intellectual curiosity, versatility, and a track record of achievement and innovation in the field of machine learning.
Engineering Program Manager
Individuals sought to coordinate the efforts of our world-class engineers and scientists in developing and building our special-purpose Anton supercomputers and proprietary software. Ideal candidates will have experience in coordinating complex technical projects and managing relationships with vendors. Successful hires will also have excellent communication skills and demonstrated leadership ability.
Scientific Software Developer
Candidates should have a demonstrated track record of academic, industrial, and/or open-source accomplishments. Relevant areas of expertise might include computational biology, Python and C/C++ programming, molecular dynamics, scientific visualization, computer graphics, full-stack web development, scientific workflow management, high performance data-parallel computing on multicore and GPU architectures, and the development of large-scale data management, cheminformatics, and/or analysis frameworks, but specific knowledge of any of these areas is less critical than intellectual curiosity, versatility, and a track record of achievement.
Computational Chemist and Physicist
D. E. Shaw Research is seeking computational and theoretical chemical physicists, as well as applied mathematicians and other computational scientists with a strong background in theory and a track record of achievement, to join our New York-based team. Relevant areas of experience might include the development of methods for molecular dynamics simulations, such as integrators or efficient approximations of long-range forces, methods for enhanced sampling or free-energy calculations, or statistical approaches for analyzing large data sets. Specific knowledge of any of these areas is less critical, however, than strong research skills, and a history of innovation and accomplishment.
D. E. Shaw Research is seeking pre-clinical translational scientists with experience in drug discovery to join our New York–based team. This is a high-visibility, high-impact role that affords the opportunity to help shape our drug discovery programs. Relevant areas of experience include leadership of pre-clinical drug discovery programs, design of in vitro assays as well as in vivo disease models, and formulation of translational plans. Specific knowledge of any of these areas is less critical, however, than strong research and communication skills, and a record of impact in drug discovery.
Software Developer for Drug Discovery
Successful hires will work on developing software that is critical to our drug discovery efforts. Ideal candidates will have extensive experience with cheminformatics software packages; strong Python and C/C++ programming skills; experience with development for cluster architectures; and familiarity with Linux/UNIX operating systems. Relevant areas of expertise include virtual screening and docking, computer-aided small molecule design, molecular modeling, and engineering of large-scale chemical databases, but specific knowledge of any of these areas is less critical than intellectual curiosity, versatility, and a track record of achievement.
Individuals sought to track and coordinate scientific, engineering, operational, and commercial projects across the group; liaise with various departments within the company and with outside firms; and assist with group-wide planning. Successful hires must have excellent communication skills, demonstrated leadership ability, strong organizational, analytical, and quantitative skills, and meticulous attention to detail.
Successful hires will be responsible for our servers and cluster environments, including massively parallel custom supercomputers, petabytes of storage, high-performance local and wide-area networks, and Linux clusters ranging from hundreds to thousands of CPU cores and GPUs. Ideal candidates should have strong fundamental knowledge of Linux concepts such as file systems, networking, and processes in addition to practical experience administering Linux systems. Candidates should also have excellent communication skills. Positions are available at our New York City office.
Individuals sought to track and coordinate scientific, engineering, operational, and commercial projects across the group; liaise with various departments within the company and with outside firms; and assist with group-wide planning. Successful hires must have excellent communication skills, demonstrated leadership ability, strong organizational, analytical, and quantitative skills, and meticulous attention to detail.
D. E. Shaw Research is seeking Ph.D. level scientists to join our New York based team. Relevant areas of experience might include direct application of molecular dynamics or machine learning to drug discovery, computer-aided drug design, molecular modeling, cheminformatics, fragment-based approaches, medicinal chemistry, biochemical and biophysical assay development, or target analysis and selection. Specific knowledge of any of these areas is less critical, however, than strong research skills, and a history of innovation and accomplishment. Successful candidates will directly further the group's drug discovery aims. This is anticipated to be a three-year position.
Highly qualified lawyer sought to manage and execute legal-related matters for the group, including but not limited to negotiating, drafting, and reviewing life sciences and technology licensing and/or collaboration agreements; coordinating intellectual property-related matters; providing high-level strategic advice; and developing internal best practices and policies. This position will involve working independently, as well as consulting with and managing external counsel from a variety of practice areas. Expertise in life sciences and/or technology licensing and transactions is strongly preferred. Successful candidates will have exceptional writing, communication, and project management skills.
D. E. Shaw Research is seeking scientists with experience in computational drug discovery or related areas to join our New York-based team. Areas of experience relevant to our molecular dynamics-based drug discovery efforts include molecular modeling, fragment-based drug design, cheminformatics, and medicinal chemistry. An ability to leverage experimental data to inform computational approaches would be a plus, as would knowledge of structural biology. Specific knowledge of any of these areas is less critical, however, than strong research skills, and a record of impact in drug discovery. Successful candidates will directly contribute to projects within our expanding portfolio of drug discovery programs, which we pursue both independently and in collaboration with leaders in academia and industry.
D. E. Shaw Research is seeking scientists with expertise in force field development to join our New York-based team. Relevant areas of experience might include development of physics-based force fields, modeling of polarization and quantum effects, novel parameterization strategies (for example, machine learning, statistical inference, or multi-objective methods), ligand and small molecule parameterization, and force field validation and verification. Specific knowledge of any particular area is less critical, however, than strong research skills, and a record of innovation and accomplishment. Successful candidates will contribute to the development of more accurate force fields for biomolecular simulation.
Individuals with excellent communication skills sought to coordinate (and contribute to) the writing and editing of manuscripts, correspond with journals, and work with the group's senior members to communicate both particular research results and the lab's long-term scientific mission. Ideal candidates should have an impressive record of academic accomplishments, a Ph.D. in chemistry, biology, physics, applied math, computer science or a similar field, and experience editing and shaping scientific publications. They should also be self-motivated critical thinkers with meticulous attention to detail and strong project management skills. Familiarity with computation and some knowledge of molecular biophysics would be an advantage.
D. E. Shaw Research is seeking postdoctoral fellows to join our New York-based team. This is a unique opportunity to develop and work with transformative technology in a dynamic, interdisciplinary environment. Candidates should have expertise in computational chemistry, biology, or physics, or in a relevant area of computer science or applied mathematics. Possible research areas for postdoctoral fellows span the scientific interests of the group, and include drug discovery, applied computational chemistry and biophysics, methodology development, and force field development.
D. E. Shaw Research is seeking early-career scientists and engineers with impressive records of achievement to join the group on a full-time basis. Serious consideration will be given to candidates with strong quantitative abilities, excellent communication skills, and a bachelor's or master's degree in the natural sciences and/or engineering. Successful candidates will work closely with a number of the world's leading biochemists, electrical engineers, and computer scientists, and will have the opportunity to make groundbreaking contributions within the fields of biology, chemistry, and medicine. Scientific Associates are expected to commit to D. E. Shaw Research for a minimum of two years; following their time at D. E. Shaw Research, previous Scientific Associates have gone on to top Ph.D. programs in the country and abroad.
