ASIC Architect and Hardware Engineer
Successful candidates will have excellent analytical and communication skills and expertise in the architecture, analysis, or implementation of hardware solutions. Particularly relevant experience would include high-speed (multi-GHz) ASIC design, current custom chip technologies, parallel computation, microprocessor architecture, machine learning acceleration, hardware/software co-design, computer arithmetic, high-speed interconnection networks, and digital systems simulation.
The expected annual base salary for this position is $200,000–$500,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
Computational Biophysicist
Candidates should have a demonstrated track record of achievement in computational chemistry, biology, or related areas of applied computational research. Relevant areas of experience might include direct application of molecular dynamics or other computational methods to drug discovery, investigation of conformational changes relevant to the function of protein kinases, ion channels, or other biomolecules, structural modeling of protein-protein complexes involved in signal transduction or other cellular processes, or study of fundamental biophysical problems, such as protein and RNA folding. Specific knowledge of any of these areas is less critical, however, than strong research skills, and a history of innovation and accomplishment.
The expected annual base salary for this position is $300,000–$450,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
Computational Chemist and Physicist
Candidates should have a demonstrated track record of achievement in computational and theoretical chemical physics, applied mathematics, or other computational sciences with a strong background in theory. Relevant areas of experience might include the development of methods for molecular dynamics simulations, such as integrators or efficient approximations of long-range forces, methods for enhanced sampling or free-energy calculations, or statistical approaches for analyzing large data sets. Specific knowledge of any of these areas is less critical, however, than strong research skills, and a history of innovation and accomplishment.
The expected annual base salary for this position is $300,000–$450,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
Successful hires will directly contribute to creating systems and infrastructure for modeling, curating, and indexing the petabytes of data generated by our special-purpose supercomputers and our large Linux HPC and GPU clusters; to implementing pipelines for processing computational and experimental data sets; and to developing and maintaining data management policies and toolkits for drug discovery data processing.
The expected annual base salary for this position is $200,000–$500,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
Ideal candidates will have a demonstrated track record of achievement in pre-clinical translational science. This is a high-visibility, high-impact role that affords the opportunity to help shape our drug discovery programs. Relevant areas of experience include leadership of pre-clinical drug discovery programs, design of in vitro assays as well as in vivo disease models, and formulation of translational plans. Specific knowledge of any of these areas is less critical, however, than strong research and communication skills, and a record of impact in drug discovery.
The expected annual base salary for this position is $300,000–$450,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
Candidates should have a Ph.D. and a demonstrated track record of academic or industrial accomplishments. Relevant areas of experience might include direct application of molecular dynamics or machine learning to drug discovery, computer-aided drug design, molecular modeling, cheminformatics, fragment-based approaches, medicinal chemistry, biochemical and biophysical assay development, or target analysis and selection. Specific knowledge of any of these areas is less critical, however, than strong research skills, and a history of innovation and accomplishment. Successful candidates will directly further the group's drug discovery aims. This is anticipated to be a three-year position.
The expected annual base salary for this position is $220,000–$240,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
Drug Discovery Operations Assistant
Individuals sought to track, report on, and help coordinate scientific, drug discovery, operational, and commercial projects in a multi-disciplinary environment; liaise with various departments within the company and with outside firms; and assist with group-wide planning. Successful hires must have excellent communication skills; superior organizational, analytical, and quantitative skills; and a meticulous attention to detail.
The expected annual base salary for this position is $100,000–$130,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
Ideal candidates will have a demonstrated track record of achievement in computational drug discovery or related areas. Areas of experience relevant to our molecular dynamics-based drug discovery efforts include molecular modeling, fragment-based drug design, cheminformatics, and medicinal chemistry. An ability to leverage experimental data to inform computational approaches would be a plus, as would knowledge of structural biology. Specific knowledge of any of these areas is less critical, however, than strong research skills, and a record of impact in drug discovery. Successful candidates will directly contribute to projects within our expanding portfolio of drug discovery programs, which we pursue both independently and in collaboration with leaders in academia and industry.
The expected annual base salary for this position is $300,000–$450,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
Financial Operations Assistant
Individuals sought to process payments for external vendors and manage purchases for the company; put together analyses and reports; oversee employee expense reimbursements; and liaise with various departments within the company and with outside firms. The position requires superior writing, organizational, and analytical ability; strong quantitative skills; and a meticulous attention to detail. Experience working with Excel and exposure to payment processing is desirable, but not required. This full-time position offers schedule flexibility, and we encourage candidates pursuing outside interests or activities to apply.
The expected annual base salary for this position is $100,000–$130,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
Candidates should have a demonstrated track record of achievement in force field development or related areas. Relevant areas of experience might include development of physics-based force fields, modeling of polarization and quantum effects, novel parameterization strategies (for example, machine learning, statistical inference, or multi-objective methods), ligand and small molecule parameterization, and force field validation and verification. Specific knowledge of any particular area is less critical, however, than strong research skills, and a record of innovation and accomplishment. Successful candidates will contribute to the development of more accurate force fields for biomolecular simulation.
The expected annual base salary for this position is $300,000–$450,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
Individuals sought to track and coordinate scientific, engineering, operational, and commercial projects across the group; liaise with various departments within the company and with outside firms; and assist with group-wide planning. Successful hires must have excellent communication skills, demonstrated leadership ability, strong organizational, analytical, and quantitative skills, and meticulous attention to detail.
The expected annual base salary for this position is $100,000–$130,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
Machine Learning Engineer
Successful hires will expand the group's ongoing efforts applying machine learning to drug discovery, biomolecular simulation, and biophysics. Ideal candidates will have demonstrated expertise in developing deep learning techniques, as well as strong Python programming skills. Relevant areas of experience might include molecular dynamics, structural biology, medicinal chemistry, cheminformatics, and/or quantum chemistry, but specific knowledge of any of these areas is less critical than intellectual curiosity, versatility, and a track record of achievement and innovation in the field of machine learning.
The expected annual base salary for this position is $250,000–$550,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
Ideal candidates will have considerable experience in structure-based drug discovery projects for multiple target classes. Relevant areas of knowledge include modern synthetic methods and analytical techniques, biochemical/biological assays, basic pharmacology and pharmaceutics, and intellectual property; experience with computational chemistry methods is not required but would be a plus. Specific knowledge of any of these areas is less critical than strong research and communication skills, and a record of impact in drug discovery, such as having advanced multiple compounds to clinical trials.
The expected annual base salary for this position is $300,000–$450,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
Candidates should have expertise in computational chemistry, biology, or physics, or in a relevant area of computer science or applied mathematics. Possible research areas for postdoctoral fellows span the scientific interests of the group, and include drug discovery, applied computational chemistry and biophysics, methodology development, and force field development.
The expected annual base salary for this position is $220,000–$240,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
D. E. Shaw Research is seeking early-career scientists with impressive records of achievement to join the group on a full-time basis. Serious consideration will be given to candidates with strong quantitative abilities, excellent communication skills, and a bachelor's or master's degree in the natural sciences and/or engineering. Successful candidates will work closely with a number of the world's leading biochemists, electrical engineers, and computer scientists, and will have the opportunity to make groundbreaking contributions within the fields of biology, chemistry, and medicine. Scientific Associates are expected to commit to D. E. Shaw Research for a minimum of two years; following their time at D. E. Shaw Research, previous Scientific Associates have gone on to top Ph.D. programs in the country and abroad.
The expected annual base salary for this position is $190,000–$210,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
Scientific Software Developer
Successful hires will contribute to software development and workflow engineering for drug discovery, including development of cheminformatics tools and algorithms; large-scale virtual screening and docking; computer-aided molecule design; development of scalable chemical databases; modeling, analysis and visualization of molecular systems; and a range of similar tasks integral to advancing our scientific and drug discovery programs
The expected annual base salary for this position is $200,000–$500,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
Software Developer for Drug Discovery
Successful hires will work on developing large-scale scientific workflows to support our drug discovery research efforts. Relevant areas of expertise might include large-scale data analysis, tool integration, workflow engineering/development, high performance data-parallel computing, systems software, machine learning, and Python programming, but specific knowledge of any of these areas is less critical than intellectual curiosity, versatility, and a track record of achievement.
The expected annual base salary for this position is $200,000–$500,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
Strategic Growth Associate
Individuals sought to formulate and execute strategies for identifying and recruiting world-class scientists and engineers. This is a dynamic, high-visibility position within the firm, which offers multiple opportunities to learn about cutting-edge science and technology, as well as to interact with the broader scientific and engineering communities. Candidates should be critical thinkers with exceptional communication and analytical skills. We are particularly interested in applicants who have undergraduate- or graduate-level experience in chemistry, biology, computer science, or engineering, but having a background in one of these areas is not a requirement.
The expected annual base salary for this position is $150,000–$225,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
Successful hires will manage systems infrastructure, networks, and information security for our servers and cluster environments, including massively parallel custom supercomputers, petabytes of storage, high-performance local and wide-area networks, and Linux clusters ranging from hundreds to thousands of CPU cores and GPUs. Ideal candidates will have strong fundamental knowledge of Linux concepts such as file systems, networking, and processes in addition to practical experience administering Linux systems. Relevant areas of expertise include large-installation systems administration experience, operational experience deploying security tools, and strong programming and scripting ability. Candidates should also have excellent communication skills. We have positions available in our New York City office and Pittsburgh data center.
The expected annual base salary for this position is $125,000–$500,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
Systems Software Developer
Ideal candidates will have a computer science or engineering degree, prior experience with non-trivial parallel or distributed systems software projects, deep knowledge of operating systems internals, strong debug skills, strong C/C++/Python programming ability, and excellent verbal and written skills. Familiarity with device drivers, Linux or BSD kernels, distributed filesystems, run-time systems, communication protocols, event-driven and thread-based concurrency, bootstrap code, x86 hardware and BIOS, and/or bringup of new hardware is a plus, but specific knowledge of any of these areas is less critical than intellectual curiosity, versatility, and a track record of achievement.
The expected annual base salary for this position is $200,000–$500,000. Our compensation package also includes variable compensation in the form of sign-on and year-end bonuses, and generous benefits. The applicable annual base salary paid to a successful applicant will be determined based on multiple factors including the nature and extent of prior experience and educational background.
A limited number of internships are available for undergraduate and graduate students seeking short-term employment. For more information about our internship program, please visit the Summer Internships page.
A limited number of internships are available for undergraduate and graduate students seeking short-term employment. For more information about our internship program, please visit the Summer Internships page.
Chemistry and Drug Discovery Intern
A limited number of internships are available for undergraduate and graduate students seeking short-term employment. For more information about our internship program, please visit the Summer Internships page.
